Given that signs and meanings pervade the world in its different aspects, semiotics is naturally open to interactions with other fields, from the humanities and social sciences to the natural and pure sciences. Open Semiotics aims to explore and expand these interactions, and to facilitate new avenues for interdisciplinary and transdisciplinary research, providing insights into a redeployment of disciplinary fields. Such an endeavor, which is intended to benefit the entire scientific community, has drawn upon extensive cooperation. This has resulted in 141 chapters authored by 178 scholars from 58 countries spanning all continents, which represent a broad array of trends and approaches as well as numerous and diverse disciplinary crossings. Open Semiotics comprises four volumes: (1) Epistemological and Conceptual Foundations, (2) Culture and Society, (3) Texts, Images, Arts, (4) Life and its Extensions. This book is the first volume of the project.